The shooting took place on the 3400 block of Claiborne Avenue, about three miles from the French Quarter.
The injured victims have been taken to an area hospital, Looney says.
There was no immediate word on their condition.
New Orleans Mayor LaToya Cantrell said in a statement that authorities will focus “every resource necessary to ending this horror and seeing justice done.”
“There is no place in New Orleans for this kind of violence. I speak for everyone in our City when I say we are disgusted, we are infuriated, and we have had more than enough,” Cantrell said. “Three more lives — gone. It has to end. This happened near my neighborhood, on the edge of Broadmoor. It’s unacceptable anywhere.”
Looney said officials are still gathering information about the shooting.